A Multi-focal View of Diabetes
Reveal Disease Mechanisms and Support Patient Stratification
By facilitating simultaneous assessment of hundreds of compounds present in living systems, metabolomics can be a critical tool used to identify biomarkers of disease development and novel targets to control Type 2 Diabetes (T2D) progression.
Most recently, Metabolon’s technology contributed to the identification of a key gut microbiome-derived compound linked to insulin resistance. A study published in Cell in 2018 helped clarify the connection between diet, the gut microbiome and processes such as glucose tolerance and insulin signaling, which are important mechanisms in the development of T2D. Revealing disease mechanisms is also vital to understanding related conditions like pre-diabetes and gestational diabetes, since both may signal a predisposition to developing a form of T2D. Therefore diabetes researchers will find value in the capability of Metabolon’s metabolomics and lipidomics services for discovering predictive biomarkers. With these tools, Metabolon is uniquely positioned to capture diabetes phenotypes through the broadest lens possible.
Understand Diabetes Treatment Mode of Action
Metabolon Can Move Your Diabetes Research Forward
See how Metabolon can advance your path to preclinical and clinical insights
Amino Acids Targeted Panel
Beta-Hydroxybutyrate Single Analyte Assay
β-Hydroxybutyrate (BHB, 3-hydroxybutyrate) is an endogenous ketone body that accumulates during periods of fasting, calorie restriction and prolonged exercise. It is created via a multi-step process involving the break-down of fatty acids into acetyl CoA, conversion to acetoacetate and reduction to β-hydroxybutyrate in the liver. BHB is the primary ketone found in the blood and is necessary for brain function especially when glucose is unavailable. It also provides neuroprotective benefits, such as relieving oxidative stress and inhibition of apoptotic pathway in cells.
Bile Acids Targeted Panel
C4 Single Analyte Assay
Central Carbons Targeted Panel
Creatinine Single Analyte Assay
Free Fatty Acids Targeted Panel
Salivary Glucose Single Analyte Assay
Impaired Glucose Tolerance Targeted Panel
Impaired Glucose Tolerance can be assessed with a single fasted blood draw by measuring a panel of selected metabolites comprised of two small organic acids (α-hydroxybutyric acid (AHB) and 4-methyl-2-oxopentanoic acid (4MOP)), 2 lipids (oleic acid and linoleoyl glycerophosphocholine (LGPC)), a ketone body (β-hydroxybutyric acid (BHBA)), an amino acid (serine), a vitamin (pantothenic acid (vitamin B5)), and glucose.
Insulin Resistance Targeted Panel
A panel of biomarkers comprised of a small organic acid (α-hydroxybutyric acid (AHB)), 2 lipids (oleic acid and linoleoylglycero-phosphocholine (LGPC)) and insulin identifies insulin resistance with a single fasting blood sample and may have value as an early indicator of risk for the development of prediabetes and type-2 diabetes.
Metabolon in Action
Biomarker Discovery in Insulin Resistance
Gut Microbiome and Diabetes
Interested in Further Studies?
Once you see the full value of metabolomics, the only remaining question is who does it best? While many laboratories have metabolite profiling or analytical chemistry capabilities, comprehensive metabolomics technologies are extremely rare. Accurate, unbiased metabolite identification across the entire metabolome introduces signal-to-noise challenges that very few labs are equipped to handle. Also, translating massive quantities of data into actionable information is slow, if not impossible, for most because proper interpretation takes two things that are in short supply: experience and a comprehensive database.
Only Metabolon has all four core metabolomics capabilities
Ability to interrogate thousands of metabolites across diverse biochemical space, revealing new insights and opportunities
Partner with Metabolon to access:
A library of 5,400+ known metabolites, 2,000 in human plasma, all referenced in the context of biochemical pathways
- That’s 5x the metabolites of the closest competitor
Unparalleled depth and breadth of experience analyzing and interpreting metabolomic data to find meaningful results
- 10,000+ projects with hundreds of clients
- 2,000+ publications covering 500 diseases, including numerous peer-reviewed journals such as Cell, Nature and Science
- Nearly 40 PhDs in data science, molecular biology, and biochemistry
Using our robust platform and visualization tools, our experts are uniquely able to tell you more about your molecule and develop assay panels to help you zero in on the results you need.
Related Metabolomics Resources
Talk with an expert
Request a quote for our services or more information on sample types and handling procedures, need a letter of support, or simply have questions about how metabolomics can advance your research.
617 Davis Drive, Suite 100
Morrisville, NC 27560
P.O. Box 110407
Research Triangle Park, NC 27709
+1 (919) 572-1711
1. Adam J, Brandmaier S, Leonhardt J, et al. Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues. Diabetes. 2016;65(12):3776-3785. doi:10.2337/db16-0512
2. Curry J, Johnson J, Tassone P, et al. Metformin effects on head and neck squamous carcinoma microenvironment: Window of opportunity trial. Laryngoscope. 2017;127(8):1808-1815. doi:10.1002/lary.26489