Cannabinoids Targeted Panel

Endocannabinoids are endogenous lipid-based neurotransmitters that bind to cannabinoid receptors (CBRs). Endocannabinoids are naturally produced by the human body. They have been shown to regulate a wide range of physiological and cognitive processes, including fertility, pregnancy, pre-and postnatal development, motor control, appetite, food intake, pain sensation, mood, memory acquisition, and learning. In humans, exercise has been shown to increase endocannabinoid levels in plasma, mainly because endocannabinoids can effectively cross the blood-brain barrier (BBB) and contribute to exercise-induced euphoria in humans. Disorders of the endocannabinoid system have been related to several neuro-inflammatory diseases, such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis. Thus, a better understanding of the endocannabinoid system in humans is an essential step toward more sophisticated exploitation of this system to improve human health further.

The quantification of endocannabinoids has been challenging due to their low abundance and structural variability. Metabolon’s targeted metabolomics enables simultaneous absolute quantification of multiple cannabinoids. The results can be used for investigating the relative changes in metabolite concentrations and potential biomarker discovery. Metabolon offers you confidence in the routine quantification of cannabinoids for your research.

The Metabolon Cannabinoids Targeted Panel measures 31 cannabinoids. The sample preparation is customized to enrich these cannabinoids, and related metabolites for much better detection than most other methods can provide. Our validated method of cannabinoid detection and identification in human plasma samples can help you gain insight into the therapeutic potential of cannabinoids in key disease states such as chronic pain and neuro-inflammatory disease. Absolute quantification of these 31 cannabinoid metabolites provides deeper insights and detects known bioactive mediators of inflammation to enable you to gain insights into the metabolic consequences of these compounds.​ The Cannabinoids Targeted Panel includes 11 endocannabinoids and related molecules​, 15 phytocannabinoids​, and 5 human metabolites of phytocannabinoids. The Cannabinoids Targeted Panel complements the Metabolon Global Discovery Panel and other inflammation-related targeted panels. With over 20 years of experience helping commercial and academic studies gain insights from metabolomic analyses and with over 3,000 citations in scientific journals, Metabolon is leading the way in applied metabolomics solutions worldwide.

*Lower Limit of Quantitation (LLOQ) varies for each sample type.

Analysis Method and Instrumentation

LC-MS/MS (Agilent 1290 UHPLC/Sciex QTrap 5500 and 6500+)

Others on request

Disclaimer: This method is for Research Use Only and is not to be used for diagnostic purposes. The sample requirements listed are for this specific panel. Additional samples will be required if running multiple panels.